Growth Regulation Hormone Assignment Example | Topics and Well Written Essays - 3000 words

Growth Regulation Hormone - Assignment Example The specific receptor of GH (GHR) is a 638-aminoacid protein, a receptor of the extrinsic tyrosine kinase group encoded on chromosome 5. It consists of an extracellular part to bind GH, a trans-membrane sequence and a cytoplasmic part. The GHR-JAK2(Janus tyrosine kinase) activation of signalling molecules can result in different cellular responses, some of which involve the activation of transcription from target genes, while others involve metabolic changes. Introduction Growth Regulatory Hormones are those hormones secreted under the control of the endocrine system. They include the Growth Hormone, somatostatins, somatomedins (IGFs) and others which are important in regulating the various aspects of growth in the body. The most important of these is the Growth Hormone (GH) which will be studied in details in this review. It is secreted from the anterior pituitary under the command of Growth Hormone Releasing Hormone of the hypothalamus and is regulated and modulated by various othe r hormones and exert its growth promoting actions by activating various signalling pathways and cross talk mechanisms which will be elucidated in this review. In this review we will specifically focus on GH and its relation to other hormones and molecular mechanisms regulating growth in the body.[1,2,3,] Growth Regulatory Hormones: A Preview Regulation of body growth is under the control of the endocrine system, which is a coordinated system of hormones secreted by special glands in the body. These hormones regulate every aspect of growth, metabolism and sexual functions also. The chief hormones regulating body growth are: Growth hormone (GH) GH, also called the somatotrophic hormone is the key regulator of growth in the body. They increase the synthesis of various proteins and elongate the bones at the growth plates. In childhood and adolescence it causes increase in height. There are other roles also like increasing the muscle mass, calcium retention in the bones and stimulating t he immune system. Growth Hormone Releasing Hormone (GHRH) The endocrine system is finely regulated for secretion of various hormones by feedback mechanisms. Thus GHRH is secreted from the hypothalamus controls the secretion of GH secretion from the pituitary gland.This means when GH pulse is low, increased GHRH secretion cause pineal gland to revive the pulse of GH and when GH pulse is high GHRH secretion decreases. Somatostatin Also called the Growth Hormone Inhibiting Hormone (GHIH) it decreases the amount of GH in the body. It is also secreted from the hypothalamus and tightly controls the release of GH in association with GHRH. Estrogen and Progesterone These hormones start the growth spurt seen in at the beginning of puberty by activating GH. They also functions to seal off the growth plates when a person reaches his adult height. These hormones start the growth spurt seen in at the beginning of puberty by activating growth hormone. They also function to seal off the growth pla tes when a person reaches his adult height. [1,2,3,4] Background of Growth Hormone Secretion Growth Hormone is secreted in a pulsatile manner from the anterior pituitary gland. It is a peptide hormone consisting of 191 amino acid residues and contains 2disulphide bonds. The 20kda and 22kda isoforms are the important ones. There are 5

Choose any topic. i dont have specific one Essay

Choose any topic. i dont have specific one - Essay Example Some people, for example state that the blacks did not resist slavery. On the contrary, blacks resisted slavery in every society. Another misconception relates to the assumption that no African influence exist on the currently culture of African Americans. Alexander and Rucker refute the misconception by stating that â€Å"many dance forms in the United States were influenced by West-Central Africans† (129) and the Charleston dance give a perfect example. Another misconception related to the lynching of black men. Most lynches were associated with accusations of sexual incidents with a white woman. However, most lynches were as a result of a black person attempting to vote, demanding their rights, or operating a successful business (Ruffins 1) The holocaust destroyed the lives of the people involved in the enslavement. It forced them to leave the comfort of their homeland for a foreign country. Consequently, it affected negatively on the social lives of those enslaved. It, for example, separated family members, leading to disintegration of the social unit. More to this, family providers who were taken into slavery left their families struggling to survive, thus causing them economic problems. Africans suffered emotional instability, given the long periods of separation from their loved ones. Young children grew up without their parents, hence forcing them to take up parental responsibilities at an early age that led to psychological imbalance. Those enslaved were succumbed to hard labor. They worked hard, leading to the prosperity of the Europe, and America at the expense of Africa. The whites amassed a lot of wealth from Africa, which they centralized, and locked up in their continent, thus boosting their prosperity. On the other hand, the enslavement denied Africans an opportunity to build their economy for many years, resulting in the under development of the African continent (Merretazon 1). Being enslaved restricts one from

How is Nagarjuna's concept of emptiness different from original Essay

How is Nagarjuna's concept of emptiness different from original Buddhist philosophical teaching - Essay Example In this way, he argued that emptiness does not represent a thing since it is not something one can point at and identify neither can one grasp it with the hand. The idea of emptiness means that things lack the element of natural being or in other words they have no soul or natural being. Nagarjuna argued that there is nothing in the world that possesses a soul or essence which means that they have no permanent unique base (Olson 167). This shows that if things do not have a natural existence or essence, it means they are not independent. Emptiness in this respect clarifies that things are fundamentally relative and therefore, cannot exist on their own. This philosophy of Nagarjuna goes against original Buddhist philosophies that identified the soul as an intrinsic being that can exist on it own even after death. Nagarjuna additionally, states that emptiness is not superior and does not judge other views because in itself it is empty. For instance, Nagarjuna touches on the issue of ex istence or non-existence and concludes that human beings overlay a personality on things that are not there. He says that the ideas of existence and non-existence are only formed in the minds of human beings which mean that emptiness destroys ignorance, gullible and blind concepts. In this way, the Four Noble Truths like knowledge and truth exist in the mind and are able to eliminate the issue of ignorance (Olson 168). It is clear from Nagarjuna viewpoint that emptiness is meant to destroy the erroneous human perception to ensure that people see things and experiences as they truly should be. He adds that emptiness is not a self-proven reality that is meant to object the issue of non-emptiness. He cites that human should therefore, not get attached to the constituent of emptiness in itself, because it is not something substantial that people need to cling onto. In Nagarjuna’s ideas, human beings should detach themselves from mental and emotional inventions since they lead peo ple to transcend their personhood. In this respect, humans are required to free themselves from any ideas or events which include the concept of emptiness. The natural nature of emptiness is emptiness which leads to the ultimate truth instead of the ultimate truth by itself (Olson 168). Nagarjuna believes that emptiness is not a concept that can be proven or defended because it is not a position at all. The concept of emptiness means that all questions end since there is no position to defend. The question of nivarna (spirit or heaven) arises and does it mean that it does not exist? In Nagarjuna explanation, there is no suggestion or intention that is legitimate in absolute sense. It is a philosophy where Nagarjuna ensures that humans understand that they need to eliminate mental and emotional attachment to extraordinary concepts and take up simple insight to the nature of things. In this respect, it is possible to understand nivarna from Nigarjuna philosophy since he says that all extraordinary things are empty which shows that nivarna is also empty. This conclusion clarifies that nivarna is devoid of any forms of unfairness, particularities and even of definitions (Olson 169). In addition, nivarna is devoid of all sorts of representations and verbal differentiations which mean it is not independent. It is clear that Nagarjuna says that nivarna and the idea of

In what ways can Australia, as a middle power, use multilateralism to Essay

In what ways can Australia, as a middle power, use multilateralism to effectively pursue its foreign policy objectives - Essay Example In the international system, it is as well the prerogative of each nation to fight for their space on the decision making table. Multilateralism as an effort to coordinate the policies of two or more nations together can hence be used by Australia (Beeson 2011). This is supported by the fact that the hierarchy places Australia at a point where it is able to bring together the lower power and the top power as an intermediary. Australia’s diplomatic practice has a strong foundation and has existed for a very long time; it is possible to discern Australian diplomatic elements, which could be said to emphasize on idealism an even legalism (Sampson & Woolcock 2003). Using the available advantage of multilateralism, Australia attempts to achieve its pursuit of foreign policy objectives in the international arena competing with not only other middle power states but also the great power states (Ball 1997). In its quest, Australia faces quite a number of possibilities as well as limit s and constraining factors. Through multilateral corporation of Australia as a middle power, the country is able to direct its efforts of whatever manner in trying to maintain international peace and security. This is one way of penetrating it policies in the international platform (2013). It is prudent to note at this point that middle power status has always defined quality of Australian foreign policy a fact that has always made Australia be a very strong negotiator and protector of its rights without simply obeying the great and mighty (Ball 1997). Such capability also makes Australia a force and to the countries advantage, they are able to bring in their policies onto the international platform. Another way in which Australia is able to use multilateralism to further its foreign policy objectives is through the application of the principle of creative middle power diplomacy. This has an extended impact of aiding the country to enhance its interests (Sampson & Woolcock 2003). Au stralia, as a middle power state, should be strategic in its alliances, as this will affect its pursuit of foreign policies. With other grater layers in the field, Australia must strive to keep up with these powers, as they are the main influential factors in the pursuit of foreign policy objectives. This has been the case with Australia as seen in various instances where Australia allied with other great powers (Ball 1997); including the USA, the super power in a strategic attempt to promote its foreign policy objectives; one notable instance is the support of Bush’s presidency in the USA by Howard’s government (Beeson 2011). The system of interdependence is an important factor that sustains interaction between states in the international syste

Gospel Music Features in the Christian Liturgy of the Pentecostal Essay

Gospel Music Features in the Christian Liturgy of the Pentecostal Church - Essay Example James (2001, p. 56) claims that the style of gospel music that exists in any given Pentecostal church depends partly on the age of the singers. Thus, the senior adult tend to prefer the transitional and traditional gospel music while, the young adults prefer modern gospel music that may predominate the main worship service. Whatever the period and age, the singing is given in the form of gospel songs in the Pentecostal churches. Development of gospel music People who were enslaved and worked in the field during the civil war told their stories in the spiritual way explaining their current life and teaching their children on the hardship they endured. When the enslaved adopted the Christian religion, their faith naturally became the focus of their songs. However, their songs were no longer limited to the spiritual because they started using the hymns written by white composers like Isaac Watts and Wesleys. The enslaved accepted the gospel music because it was attributed to their style and culture, especially the meter hymn that is still used in the most Pentecostal churches. As the civil war came to an end and enslaved were finally emancipated, it marked the beginning of what is referred to the historical gospel hymns. According to James (2001, p. 55), these songs flourished during the social and economic deprivation of depression and started to make their way out of the Pentecostal churches. According to Anderson and James (2007, p. 285) indicate that the civil rights movement brought rebirth of older songs, especially spiritual songs that became the freedom songs. These spiritual songs were the bridge between what is known as historical gospel and modern gospel songs. The publicizing of the Pentecostal churches and protest brought a wider exposure to the gospel music and its popularity spread. Currently, the modern gospel is one of the most popular sounds in the music industry. In the twentieth century, the most widespread and celebrated of the people traditio n was the growth and development of gospel music, especially in the Pentecostal churches. These churches were visited by the traveling musicians and evangelists from the Chicago gospel scene like Sallie Martin and Thomas Dorsey. Despite this contact with new gospel sounds, arranged spirituals, and hymns were still popular styles of church music. Pastors and Pentecostal churches supported the expansion of gospel music by starting gospel choirs and hosting outstanding concerts in various Pentecostal churches like opportunity Baptist. Various composers started transcribing and publishing their gospel music and gospel performers protected themselves from exploitation by forming gospel unions. Anderson and James (2007, p. 289) indicate that the gospel growth extended beyond churches in the black community and moved to worldly white venues around the city. Most of the gospel composers and performers received attention via television programs, firms and release of albums by choirs. Thus, t he developed technology has assisted a lot in developing the gospel music worldwide. Many gospel singers have developed new styles of singing and different, exciting music ministries. From neo spiritual to the modern gospel and praise and worship music, these song writers reflect the range of gospel music in Pentecostal churches today. The gospel music composers Wallace (2005, P. 104) indicates that the gospel music was brought substantial change in the Pentecosta

Legal Personality and Limited Liability Essay Example | Topics and Well Written Essays - 1000 words

Legal Personality and Limited Liability - Essay Example The law is prepared sometimes to examine the company faade and this process is described as piercing or lifting the corporate veil. The fact that a company is a unit that is thought as legal and free from its owners can sometimes produce undesirable results. For instance, shareholders can obtain funds illegally and then be regarded as not liable to repay or in a case where the directors are liable of fraudulent activities. The courts have been forced to intervene in some circumstances and disregard the doctrine of limited liability and corporate personality especially the case of group companies and their subsidiaries where the entity form is being manipulated as a tool to commit fraud. The case of Salomon Vs Salomon & Co. Ltd in 1987 established the irrevocability position in common law of legal personality and limited liability of companies (Butterworth, 1960, p.6). Some of the circumstances that lead to court intervention include the following: trading with an enemy, the case for sham companies, failure to comply with the legislation laws, fraudulent and wrongful trading, disqualified director's actions and statutory power abuse. For instance if a company is a sham one i.e. formed to enable one avoid obligations such as tax, the court may act to ignore the company's existence. In case the court discovers that a fraud is committed, it is prep... The fraud will notably be a case where a company owner used the company intentionally to deny his creditors their legal rights. It discourages Solomon principle to act as a vehicle of fraud. The exemption which illustrates fraud are found in Gilford Motor Ltd Vs Jones Lipman. In this case, Mr. Horne who was as ex -employee of the company incorporated another limited company in his spouse's name. In so doing, he solicited the clients of Gilford Motor ltd as his employment contract held it clear that he cannot solicit customers of the organization. The court held that the company's idea behind its formation was to commit fraud and to mask Mr. Hornes' effective continuation of the business. The court held that it was a sham to mask his wrongdoings as it was very clear that the objective of incorporating that company was to commit fraud. The court at it discretion may impose liability on people liable for carrying out the business with an intention of defrauding the creditors at the wind ing up of the business. The directors are also liable if they sign a cherub or a bill of exchange on company's behalf and fail to include the company's name, omits a word or writes it incomplete (Oliver, 1971, p.66). Common law provides for separate legal entity of a company and the court disregarded this legal personality and instead has investigated the shareholders personal quality or those who usually controls the company. The reason behind this is because it is the public interest to make sure that the company is not run by an undesirable person and that it is not under any criminal element. Trading with an enemy especially during the time of war is another instance that leads to lifting of the veil of incorporation. In Daimler Company

Criminal Justice Bill of 2003 Essay Example | Topics and Well Written Essays - 1500 words

Criminal Justice Bill of 2003 - Essay Example The proposal says that there are fundamental problems, first in the investigation process and then in subsequent trial. The seriousness of the alleged office and the mentality that leads to such offence should be fathomed by jury because a careless acquittal or a ready acceptance of non-existing innocence could spell abortive justice though it is difficult to achieve unanimity in this matter . As it is establishment of fraud is a highly time consuming procedure warranting diverse evidence and corroborative facts. If judge has to educate jury on all of them it is naturally further waste of Court time. All investigation cannot claim transparency and it is neither easy nor compulsory to have it. Commercial investigation might involve even distant parties and inside knowledge of such parties’ financial dealings might encourage jurors to use it later for their own advantage. There might be juries who had fallen prey to fraudulent financial issues and might have developed bias towar ds fraudulency and such jurors will be prejudiced while dealing with the case . If it is necessary to choose sides, perhaps it is better to have trials without the jury. First of all, it is the right of the Court to decide on the trial and not that of the defendant, as told by Lord Justice Auld . He also recommended for creation of an ‘intermediate’ Court with a bench consisting of a District Judge and two Magistrates and Government rejected this idea, but the Minister agreed that such arrangement could be considered in certain cases . Clause 36 will allow the defendant to opt out of jury trial by making an application and the judge will examine the feasibility. If there is a co-defendant, his views are of paramount importance . There are mixed reactions to this issue and the Bar Council and the Criminal Bar Association were rather uncomfortable and opined: â€Å"Rather than trying a cross section of cases and defendants, judges are likely under these proposals to have a diet of unpopular sexual allegations; unattractive middle or upper class fraudsters; and cases where the defence lawyers hope for a technical victory, either in the court of trial, or on appeal following defects in the reasoned judgment" . Roger Smith, Director of Justice said: â€Å"the jury is often presented as something which is to defend the defendant's interest; it is actually wider than that. The jury protects the public's interest in the system. That is not just the defendant; it is a protection for the professional judiciary in the system because they take the decision on guilt or innocence" (Ibid). The Select Committee on Home Affairs supported the view expressed by Lord Judge Auld.